The goal is to use Shard of the Spire with Momentum Builder and / or Recurring Nightmare, then force through Overwhelm damage using Savagery on your most likely target.
Recurring Nightmare's interaction is especially interesting as Shard will continue to increase its health in proportion to any strength gained from the infiltrate, allowing damage to be pushed through with Killer every turn as the Nightmare will become capable of surviving vs. blockers.
As has been pointed out several times by stream chat, Dark Return may be a better card than Scream in this deck because of the Inspire units; I see Scream as a game ender for use with units that have already been Inspired / come down with Shard on the board.
Vara, Vengeance Seeker is also a consideration for this deck as a screamable Deadly, Killer, Overwhelm unit with Lifesteal that gets bigger every time she's screamed is pretty okay.
Hoping to play it in the latest version!